Zusammenfassung
Die Ileokoloskopie mit Stufenbiopsien ist die wichtigste Untersuchung bei Verdacht
auf eine chronisch entzündliche Darmerkrankung. In ca. 90 % ist eine Differenzierung
zwischen einer Colitis ulcerosa und einem M. Crohn bereits zu Beginn möglich. Spezifische
standardisierte Befundinhalte erhöhen die Aussagekraft und erlauben eine Vergleichbarkeit
der Befunde. Bei bereits gesicherter Diagnose soll eine (Ileo-)Koloskopie nur bei
gezielter Fragestellung durchgeführt werden. Eine Ösophagogastroduodenoskopie ist
nur bei Beschwerden des oberen Verdauungstraktes indiziert. Die Kapselendoskopie bzw.
Push-Enteroskopie ist derzeit nur bestimmten Fragestellungen vorbehalten. Chronisch
entzündliche Darmerkrankungen mit ausgedehntem Dickdarmbefall sind mit einem erhöhten
Risiko für kolorektale Karzinome assoziiert. Regelmäßige Vorsorge-Koloskopien mit
sorgfältiger Biopsieentnahme ermöglichen den Nachweis prämaligner Läsionen und stellen
die Grundlage für eine effektive Krebsprophylaxe dar.
Abstract
Ileocolonoscopy including biopsies is the first line investigation in suspected inflammatory
bowel disease (IBD). In up to 90 % of the cases ulcerative colitis and Crohn’s disease
are differentiated on endoscopic presentation. Standardised reporting of endoscopic
results increases the validity and comparability of IBD findings. When there is a
firm diagnosis of IBD, colonoscopy should only be performed for specific questions.
An upper gastrointestinal endoscopy is only indicated in patients with upper gastrointestinal
symptoms. Push and capsule endoscopy should also be limited to specific questions
and situations. IBD with extended colitis is associated with an increased risk for
colorectal cancer. Endoscopic surveillance with accurate biopsy sampling is a valuable
tool for the prevention of colorectal cancer.
Schlüsselwörter
Darm - Colitis ulcerosa - Morbus Crohn - chronisch entzündliche Darmerkrankung
Key words
intestines - ulcerative colitis - Crohn’s disease - chronic inflammatory bowel disease
Literatur
1
Feffermann D R, Farrel R J.
Endoscopy in inflammatory bowel disease: Indications, surveillance and use in clinical
practice.
Clin Gastroenterol Hepatol.
2005;
3
11-24
2
De Lange T, Moum B A, Tholfsen J K. et al .
Standardization and quality of endoscopy text reports in ulcerative colitis.
Endoscopy.
2003;
35
835-840
3
Geboes K, Ectors N, D’Haens G. et al .
Is ileoscopy with biopsy worthwhile in patients presenting with symptoms of inflammatory
bowel disease?.
Am J Gastroenterol.
1998;
93
201-206
4
Lewis B S.
Ileoscopy should be part of standard colonoscopy.
J Clin Gastroenterol.
2000;
31
103-104
5
Pera A, Bellando P, Caldera D. et al .
Colonoscopy in inflammatory bowel disease. Diagnostic accuracy and proposal of an
endoscopic score.
Gastroenterology.
1987;
92
181-185
6
Moum B, Ekbom A, Vatn M H. et al .
Clinical course during the 1st year after diagnosis in ulcerative colitis and Crohn’s
disease. Results of a large, prospective population-based study in southeastern Norway,
1990 - 93.
Scand J Gastroenterol.
1997;
32
1005-1012
7
D’Haens G, Geboes K, Peeters M. et al .
Patchy cecal inflammation associated with distal ulcerative colitis: a prospective
endoscopic study.
Am J Gastroenterol.
1997;
92
1275-1279
8
Okawa K, Aoki T, Sano K. et al .
Ulcerative colitis with skip lesions at the mouth of the appendix: a clinical study.
Am J Gastroenterol.
1998;
93
2405-2410
9
Hill M D, Davies G, McIntyre A S. et al .
Proctitis with caecitis: an atypical presentation of ulcerative colitis.
Endoscopy.
2002;
34
664-666
10
Chiba M, Yamano H, Fujiwara K. et al .
Lymph folliculitis in ulcerative colitis.
Scand J Gastroenterol.
2001;
36
332-336
11
Gardiner G A.
„Backwash Ileitis” with Pseudopolyposis.
Am J Roentgenol.
1977;
128
505-507
12
Niv Y, Bat L, Ron E. et al .
Change in the extent of colonic involvement in ulcerative colitis: A Colonoscopic
Study.
Am J Gastroenterol.
1987;
82
1046-1051
13
Moum B, Ekbom A, Vatn M H. et al .
Change in the extent of colonoscopic and histological involvement in ulcerative colitis
over time.
Am J Gastroenterol.
1999;
94
1564-1569
14
De Lange T, Larsen S, Aabakken L.
Inter-observer agreement in the assessment of endoscopic findings in ulcerative colitis.
BMC Gastroenterol.
2004;
4
9
15
Baron J H, Connel A M, Lennard-Jones J E.
Variation between observers in describing mucosal appearances in proctocolitis.
BMJ.
1964;
1
89-92
16
Powell-Tuck J, Day D W, Buckell N A. et al .
Correlations between defined sigmoidoscopic appearances and other measures of disease
activity in ulcerative colitis.
Dig Dis Sci.
1982;
27
533-537
17
Sutherland L R, Martin F, Greer S. et al .
5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis,
and proctitis.
Gastroenterology.
1987;
92
1894-1898
18
Rutegard I, Ahsgren L, Stenling R. et al .
A simple index for assessment of disease activity in patients with ulcerative colitis.
Hepatogastroenterology.
1990;
37 (Suppl 2)
110-112
19
Schroeder K W, Tremaine W J, Ilstrup D M.
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative
colitis. A randomized study.
N Engl J Med.
1987;
317
1625-1629
20
Rachmilewitz D.
Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of
active ulcerative colitis: a randomized study trial.
BMJ.
1989;
298
82-86
21
Carbonnel F, Lavergne A, Lemann M. et al .
Colonoscopy of acute colitis. A safe and reliable tool for assessment of severity.
Dig Dis Sci.
1994;
39
1550-1557
22
Alemayehu G, Jarnerot G.
Colonoscopy during an attack of severe ulcerative colitis is a safe procedure and
of great value in clinical decision making.
Am J Gastroenterol.
1991;
86
187-190
23
Hyde G M, Jewell D P.
Review article: the management of severe ulcerative colitis.
Aliment Pharmacol Ther.
1997;
11
419-424
24
Marion J F, Present D H.
The modern medical management of acute, severe ulcerative colitis.
Eur J Gastroenterol Hepatol.
1997;
9
831-835
25
Buckell N A, Williams G T, Bartram C I. et al .
Depth of ulceration in acute colitis: correlation with outcome and clinical and radiologic
features.
Gastroenterology.
1980;
79
19-25
26
Carbonnel F, Gargouri D, Lemann M. et al .
Predictive factors of outcome of intensive intravenous treatment for attacks of ulcerative
colitis.
Aliment Pharmacol Ther.
2000;
14
273-279
27
Gelbmann C.
Prediction of treatment refractoriness in ulcerative colitis and Crohn’s disease -
do we have reliable markers?.
Inflamm Bowel Dis.
2000;
6
123-131
28
Modigliani R, Mary J Y, Simon J F. et al .
Clinical, biological, and endoscopic picture of attacks of Crohn’s disease. Evolution
on prednisolone. Groupe d’Etude Therapeutique des Affections Inflammatoires Digestives.
Gastroenterology.
1990;
98
811-818
29
D’Haens G, Van Deventer S, Van Hogezand R. et al .
Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies
in Crohn’s disease: A European multicenter trial.
Gastroenterology.
1999;
116
1029-1034
30
Daperno M, D’Haens G, Van Assche G. et al .
Development and validation of a new, simplified endoscopic activity score for Crohn’s
disease: the SES-CD.
Gastrointest Endosc.
2004;
60
505-512
31
Nahon S, Bouhnik Y, Lavergne-Slove A. et al .
Colonoscopy accurately predicts the anatomical severity of colonic Crohn’s disease
attacks: correlation with findings from colectomy specimens.
Am J Gastroenterol.
2002;
97
3102-3107
32
Stange E F, Travis S P, Vermeire S. et al .
European Crohn’s and Colitis Organisation. European evidence based consensus on the
diagnosis and management of Crohn’s disease: definitions and diagnosis.
Gut.
2006;
55 (Suppl 1)
i1-i5
33
Allez M, Lemann M, Bonnet J. et al .
Long term outcome of patients with active Crohn’s disease exhibiting extensive and
deep ulcerations at colonoscopy.
Am J Gastroenterol.
2002;
97
947-953
34
Rutgeerts P, Geboes K, Vantrappen G. et al .
Predictability of the postoperative course of Crohn’s disease.
Gastroenterology.
1990;
99
956-963
35
D’Haens G, Noman M, Baert F. et al .
Endoscopic healing after Infliximab treatment for Crohn’s disease provides a longer
time to relapse.
Gastroenterology.
2002;
122
A100
36
Landi B, Anh T N, Cortot A. et al .
Endoscopic monitoring of Crohn’s disease treatment: a prospective, randomised clinical
trial. The Groupe d’Etudes Therapeutiques des Affections Inflammatoires Digestives.
Gastroenterology.
1992;
102
1647-1653
37
Sandborn W J, Tremaine W J, Batts K P. et al .
Pouchitis after ileal pouch-anal anastomosis: a Pouchitis Disease Activity Index.
Mayo Clin Proc.
1994;
69
409-415
38
D’Haens G, Geboes K, Rutgeerts P.
Endoscopic and histologic healing of Crohn’s (ileo-) colitis with azathioprine.
Gastrointest Endosc.
1999;
50
667-671
39
D’Haens G.
Mucosal healing in Pediatric Crohn’s Disease.
Inflamm Bowel Dis.
2004;
10
479-480
40
Nishimoto Y, Matsumoto T, Suekane H. et al .
Cytomegalovirus infection in a patient with ulcerative colitis: colonoscopic findings.
Gastrointest Endosc.
2001;
53
816-818
41
Shen B, Fazio V W, Remzi F H. et al .
Endoscopic balloon dilation of ileal pouch strictures.
Am J Gastroenterol.
2004;
99
2340-2347
42
Breysem Y, Janssens J F, Coremans G. et al .
Endoscopic balloon dilation of colonic and ileo-colonic Crohn’s strictures: long-term
results.
Gastrointest Endosc.
1992;
38
142-147
43
Thomas-Gibson S, Brooker J C, Hayward C M. et al .
Colonoscopic balloon dilation of Crohn’s strictures: a review of long-term outcomes.
Eur J Gastroenterol Hepatol.
2003;
15
485-488
44
Blomberg B, Rolny P, Jarnerot G.
Endoscopic treatment of anastomotic strictures in Crohn’s disease.
Endoscopy.
1991;
23
195-198
45
Sabate J M, Villarejo J, Bouhnik Y. et al .
Hydrostatic balloon dilatation of Crohn’s strictures.
Aliment Pharmacol Ther.
2003;
18
409-413
46
Hommes D W, van Deventer S J.
Endoscopy in inflammatory bowel disease.
Gastroenterology.
2004;
126
1561-1573
47
Saunders B P, Brown G J, Lemann M. et al .
Ballon dilation of ileocolonic strictures in Crohn’s disease.
Endoscopy.
2004;
36
1001-1007
48
Couckuyt H, Gevers A M, Coremans G. et al .
Efficacy and safety of hydrostatic balloon dilation of ileocolonic Crohn’s strictures:
a prospective longterm analysis.
Gut.
1995;
36
577-580
49
Dear K L, Hunter J O.
Colonoscopic hydrostatic balloon dilatation of Crohn’s strictures.
J Clin Gastroenterol.
2001;
33
315-318
50
Lavy A.
Triamcinolone improves outcome in Crohn’s disease strictures.
Dis Colon Rectum.
1997;
40
184-186
51
Ramboer C, Verhamme M, Dhondt E. et al .
Endoscopic treatment of stenosis in recurrent Crohn’s disease with balloon dilatation
combined with local corticoid injection.
Gastrointest Endosc.
1995;
42
252-255
52
Brooker J C, Beckett C G, Saunders B P. et al .
Long acting steroid injection after endoscopic dilation of anastomotic Crohn’s strictures
may improve the outcome: a retrospecticve case series.
Endoscopy.
2003;
35
333-337
53
Matsuhashi N, Nakajima A, Suzuki A. et al .
Long-term outcome of non-surgical strictureplasty using metallic stents for intestinal
strictures in Crohn’s disease.
Gastrointest Endosc.
2000;
51
343-345
54
Rutter M, Saunders B, Emmanuel A. et al .
Endoscopic snare polypectomy for bleeding postinflammatory polyps.
Endoscopy.
2003;
35
788-790
55
Yoshida Y, Kawaguchi A, Mataki N. et al .
Endoscopic treatment of massive lower GI hemorrhage in two patients with ulcerative
colitis.
Gastrointest Endosc.
2001;
54
779-781
56
Oberhuber G, Puspok A, Oesterreicher C. et al .
Focally enhanced gastritis: a frequent type of gastritis in patients with Crohn’s
disease.
Gastroenterology.
1997;
112
698-706
57
Kundhal P S, Stormon M O, Zachos M. et al .
Gastral antral biopsy in the differentiation of pediatric colitides.
Am J Gastroenterol.
2003;
98
557-561
58
Wagtmans M J, van Hogezand R A, Griffioen G. et al .
Crohn’s disease of the upper gastrointestinal tract.
Neth J Med.
1997;
50
S2-7
59
Schmitz-Moorman P, Malchow H, Pittner P M.
Endoscopic and bioptic study of the upper gastrointestinal tract in Crohn’s disease.
Path Res Pract.
1985;
179
377-87
60
Haggitt R C, Meissner W A.
Crohn’s disease of the upper gastrointestinal tract.
Am J Clin Pathol.
1973;
59
613-622
61
Hokama A, Kinjo F, Sugama R. et al .
Gastrointestinal: duodenal Crohn’s disease.
J Gastroenterol Hepatol.
2003;
18
1425
62
Culliford A, Markowitz D, Rotterdam H. et al .
Scalloping of duodenal mucosa in Crohn’s disease.
Inflamm Bowel Dis.
2004;
10
270-273
63
Castellaneta S P, Afzal N A, Greenberg M. et al .
Diagnostic role of upper gastrointestinal endoscopy in pediatric inflammatory bowel
disease.
J Pediatr Gastroenterol Nutr.
2004;
39
257-261
64
Ramaswamy K, Jacobson K, Jevon G. et al .
Esophageal Crohn disease in children: a clinical spectrum.
J Pediatr Gastroenterol Nutr.
2003;
36
454-458
65
Murthy U.
Repeated hydrostatic ballon dilatation in obstructive gastroduodenal Crohn’s disease.
Gastrointest Endoscopy.
1991;
37
484-485
66
Kornbluth A, Legnani P, Lewis B S.
Video capsule endoscopy in inflammatory bowel disease: past, present, and future.
Inflamm Bowel Dis.
2004;
10
278-285
67
Buchman A L, Miller F H, Wallin A. et al .
Videocapsule endoscopy versus barium contrast studies for the diagnosis of Crohn’s
disease recurrence involving the small intestine.
Am J Gastroenterol.
2004;
99
2171-217
68
Fireman Z, Mahajna E, Broide E. et al .
Diagnosing small bowel Crohn’s disease with wireless capsule endoscopy.
Gut.
2003;
52
390-392
69
Papadakis K A, Lo S K, Fireman Z. et al .
Wireless capsule endoscopy in the evaluation of patients with suspected or known Crohn’s
disease.
Endoscopy.
2005;
37
1018-1022
70
Eliakim R, Suissa A, Yassin K. et al .
Wireless capsule video endoscopy compared to barium follow-through and computerised
tomography in patients with suspected Crohn’s disease - final report.
Dig Liver Dis.
2004;
36
519-522
71
Herrerias J M, Caunedo A, Rodriguez-Tellez M. et al .
Capsule endoscopy in patients with suspected Crohn’s disease and negative endoscopy.
Endoscopy.
2003;
35
564-568
72
Chong A K, Taylor A, Miller A. et al .
Capsule endoscopy vs. push enteroscopy and enteroclysis in suspected small-bowel Crohn’s
disease.
Gastrointest Endosc.
2005;
61
255-261
73
De Palma G D, Rega M, Puzziello A. et al .
Capsule endoscopy is safe and effective after small-bowel resection.
Gastrointest Endosc.
2004;
60
135-138
74
Graham D Y, Opekun A R, Willingham F F. et al .
Visible small-intestinal mucosal injury in chronic NSAID users.
Clin Gastroenterol Hepatol.
2005;
3
55-59
75
Goldstein J L, Eisen G M, Lewis B. et al .
Video capsule endoscopy to prospectively assess small bowel injury with celecoxib,
naproxen plus omeprazole, and placebo.
Clin Gastroenterol Hepatol.
2005;
3
133-141
76
Eaden J, Abrams K R, Mayberry J F.
The risk of colorectal cancer in ulcerative colitis: a meta-analysis.
Gut.
2001;
48
526-535
77
Ekbom A, Helmick C, Zack M. et al .
Increased risk of large-bowel cancer in Crohn’s disease with colonic involvement.
Lancet.
1990;
226
357-359
78
Gillen C D, Walmsley R S, Prior P. et al .
Ulcerative colitis and Crohn’s disease: a comparison of the colorectal cancer risk
in extensive colitis.
Gut.
1994;
35
1590-1592
79
Ekbom A, Helmick C, Zack M. et al .
Ulcerative colitis and colorectal cancer: a population-based study.
N Engl J Med.
1990;
323
1228-1233
80
Rutter M, Saunders B, Wilkinson K. et al .
Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis.
Gastroenterology.
2004;
126
451-459
81
Askling J, Dickman P W, Karlén P. et al .
Family history as a risk factor for colorectal cancer in inflammatory bowel disease.
Gastroenterology.
2001;
120
1356-1362
82
Nuako K W, Ahlquist D A, Mahoney D W. et al .
Familial predisposition for colorectal cancer in chronic ulcerative colitis: a case-control
study.
Gastroenterology.
1998;
115
1079-1083
83
Eaden J, Abrams K, Ekbom A. et al .
Colorectal cancer prevention in ulcerative colitis: a case-control study.
Aliment Pharmacol Ther.
2000;
14
145-153
84
Velayos F S, Loftus E V Jr, Jess T. et al .
Predictive and protective factors associated with colorectal cancer in ulcerative
colitis: a case-control study.
Gastroenterology.
2006;
130
1941-1949
85
Rutter M D, Saunders B P, Wilkinson K H. et al .
Cancer surveillance in longstanding ulcerative colitis: endoscopic appearance help
predict cancer risk.
Gut.
2004;
52
1813-1816
86
Jayaram H, Satsangi J, Chapman R WG.
Increased colorectal neoplasia in chronic ulcerative colitis complicated by primary
sclerosing cholangitis: fact or fiction?.
Gut.
2001;
48
430-434
87
Riddell R H, Goldman H, Ransohoff D F.
Dysplasia in inflammatory bowel disease: standardized classification with provisional
clinical applications.
Hum Pathol.
1983;
14
931-968
88
Schlemper R J, Ridell R H, Kato Y. et al .
The Vienna classification of gastrointestinal epithelial neoplasia.
Gut.
2000;
47
251-255
89
Itzkowitz S H, Harpaz N.
Diagnosis and management of dysplasia in patients with inflammatory bowel diseases.
Gastroenterology.
2004;
126
1634-1648
90
Lim C H, Dixon M F, Vail A. et al .
Ten year follow up of ulcerative colitis patients with and without low grade dysplasia.
Gut.
2003;
52
1127-1132
91
Blackstone M O, Ridell R H, Rogers B HG. et al .
Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in long-standing
ulcerative colitis: an indication for colectomy.
Gastroenterology.
1981;
80
366-374
92
Vatn M H, Stalsberg H.
The prevalence of polyps of the large intestine in Oslo.
Cancer.
1982;
49
819-925
93
Williams A R, Balasooriya B AW, Day D W.
Polyp and cancer of the large bowel. A necropsy study in Liverpool.
Gut.
1982;
23
835-842
94
Schneider A, Stolte M.
Differential diagnosis of adenomas and dysplastic lesions in patients with ulcerative
colitis.
Z Gastroenterol.
1993;
31
653-656
95
Torres C, Antonioli D, Odze R D.
Polypoid dysplasia and adenomas in inflammatory bowel disease.
Am J Surg Pathol.
1998;
22
275-284
96
Harpaz N.
Adenoma-like dysplastic polyps in inflammatory bowel disease.
Pathology Case Reviews.
2004;
9
135-141
97
Rubin P H, Friedman S, Harpaz N. et al .
Colonoscopic polypectomy in chronic colitis: conservative management after endoscopic
resection of dysplastic polyps.
Gastroenterology.
1999;
117
1295-1300
98
Engelsgjerd M, Farraye F A, Odze R D.
Polypectomy may be adequate treatment for adenoma-like dysplastic lesions in chronic
ulcerative colitis.
Gastroenterology.
1999;
117
1288-1294
99
Bernstein C N, Shanahan F, Weinstein W M.
Are we telling patients the truth about surveillance colonoscopy in ulcerative colitis?.
Lancet.
1994;
343
71-74
100
Ullman T A, Loftus E V Jr, Kakar S. et al .
The fate of low-grade dysplasia in ulcerative colitis.
Am J Gastroenterol.
2002;
97
922-927
101
Befrits R, Ljung T, Jaramillo E. et al .
Low-grade dysplasia in extensive, long-standing inflammatory bowel disease: a follow-up
study.
Dis Colon Rectum.
2002;
45
615-620
102
Ullmann T A, Croog T, Harpaz N. et al .
Progression of low-grade dysplasia to advanced neoplasia in patients with ulcerative
colitis.
Gastroenterology.
2003;
125
1311-1319
103
Lim D H, Dixon M F, Vail A. et al .
Ten year follow up of ulcerative colitis patients with and without low-grade dysplasia.
Gut.
2003;
52
1127-1132
104
Karlén P, Kornfeld D, Broström O. et al .
Is colonoscopic surveillance reducing colorectal cancer mortality in ulcerative colitis?
A population based case control study.
Gut.
1998;
42
711-714
105
Choi P M, Nugent F W, Schoetz D J.
Colonoscopic surveillance reduces mortality from colorectal cancer in ulcerative colitis.
Gastroenterology.
1993;
105
418-424
106
Rubin C E, Haggitt R C, Burmer G C. et al .
Aneuploidy in colonic biosies predicts future development of dysplasia in ulcerative
colitis.
Gastroenterology.
1992;
103
1611-1620
107
Rutter M D, Saunders B P, Schofield G. et al .
Pancolonic indigo carmine dye spraying for the detection of dysplasia in ulcerative
colitis.
Gut.
2004;
53
256-260
108
Kiesslich R, Fritsch J, Holtmann M. et al .
Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia
and colon cancer in ulcerative colitis.
Gastroenterology.
2003;
124
880-888
109
Eaden J A, Mayberry J F.
Guidelines for screening and surveillance of asymtomatic colorectal cancer in patients
with inflammatory bowel disease.
Gut.
2002;
51
v10-v12
Prof. Dr. Wolfgang Petritsch
Department of (Internal Medicine), Medical University Graz
Auenbruggerplatz 15
8036 Graz, Österreich
Phone: ++43/3 16/3 85 43 86
Fax: ++43/3 16/3 85 43 87
Email: wolfgang.petritsch@meduni-graz.at